Ace NURS 3100 Exam 1 in 2025 – Your Ultimate Nursing Adventure Starts Here!

Question: 1 / 400

A nurse is reviewing drug safety with a student nurse. The nurse explains that the median lethal dose of drugs is often determined in laboratory preclinical trials because of which factors? (Select all that apply)

It is difficult to obtain sufficient participants for clinical trials

Clinical trials determine the safety profile of a drug, but these trials require a large number of participants which can be difficult to obtain. Additionally, it would be unethical to expose human subjects to potentially lethal doses of a drug, which is why the median lethal dose is often determined in laboratory preclinical trials. Clinical trials also tend to focus on determining the effective dose of a drug rather than its lethal dose. Lastly, conducting studies during clinical trials can be costly, making it more practical to determine the median lethal dose beforehand in laboratory settings.

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It would be unethical to determine these values in human subjects

The safety of the medication must be determined prior to clinical trials

Clinical trials determine only the effective dose of a drug

It is too costly to conduct the studies during clinical trials

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